Bioinorganic Chemistry (BioAno)   

SEMESTER LEARNING PLAN

Document can be downloaded here

 

Course Title: Bioinorganic Chemistry (BioAno)   

MK code: AKM21 463

Credit Weight: 2

Group of Courts: elective

Semester: 6

Prerequisite Course: Kano3

 

Lecturer:

Sriatun, M.Si

Drs. Suhartana, M.Si

 

Graduate Learning Outcomes (GLO)

  Attitude GLO1-(S9) Demonstrate an attitude of responsibility for work in their field of expertise independently.
Knowledge GLO2-(PP1) Mastering the theoretical concepts of structure, properties, changes, kinetics, and energetics of molecules and chemical systems, identification, separation, characterization, transformation, synthesis of micromolecular chemicals and their application
General Skills GLO4 -(KU1) Able to apply logical, critical, systematic, and innovative thinking in the context of the development or implementation of science and technology that pays attention to and uses humanities values by their field of expertise
Special skill GLO8 -(KK3) Able to analyze several alternative solutions in identification, analysis, isolation, transformation, and synthesis of chemicals available and present analysis conclusions for appropriate decision-making.

Course Description

In this course, students learn about Industrial chemical processes, process engineering, and how to design processes based on the principles they have learned. In the discussion and presentation of assignments using discovery learningcooperative learningcollaborative learning, and problem-based learning/case studies. The hope in the discussion is that there will be cooperative and collaborative communication between students/groups.

 

Week Expected ability (Sub-CLO) Study Materials/ Learning Materials Learning methods Student Learning Experience Time (minutes) Evaluation
Criteria and Indicators %
1 Sub-CLO 1:

Able to understand (C2), construct (P4) and discuss (A2) essential inorganic chemistry

Essential chemical elements, Metals in biological systems Discovery learning

Cooperative learning

Discusses the problem of essential chemical elements and some metals in biological systems, then concludes the problem/task given by the lecturer in groups FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy describes the essential chemical elements for living things

2. Accuracy in explaining the role of metals involved in a particular biological system

10
2 Sub-CLO 2:

Able to understand (C2), construct (P4) and discuss (A2) essential inorganic chemistry

Metal ion complexation

Electronic structures and metal geometries in biological systems

Discovery learning

Cooperative learning

They discussed problems in groups: the formation of complexes between metal ions and organic ligands/biomolecules and how their electronic structures and geometries are in biological systems FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in explaining how the complex is formed

 

2. Accuracy in explaining the electronic structure and geometric shape of molecules in biological systems

5
3 Sub-CLO 3:

Able to understand (C2), compose (P4), and discuss (A2) essential inorganic chemistry

Kimia Bioorganologam, Transfer elektron Discovery learning

Cooperative learning

Problem Based Learning

Discuss in small groups about organometallic problems in biological systems and electron transfer that occurs in the molecules involved FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in explaining organometallic in biological systems

2. Accuracy in describing the transfer of electrons between molecules in biological systems

5
4 Sub-CLO 4:

Able to understand (C2), compose (P4), and discuss (A2)

Elemental transport, transfer and transcription

Transport sodium and potassium 2 Calcium signaling proteins Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude problems/tasks in groups about how the transport of sodium and potassium in living cells occurs, how calcium signaling protein occurs FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in explaining the occurrence of sodium and potassium transport

2. Accuracy in describing about calcium signaling protein

5
5 Sub-CLO 5:

Able to understand (C2), compose (P4), and discuss (A2) Elemental transport, transfer, and transcription

-Zinc in transcription

-Selective transport and storage of elemental iron:

a. Siderophore and phytosiderophore

b. Transferrin, ferritin,

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturers in groups regarding the transcription of zinc elements, how the transport of the essential component of iron occurs in microorganisms and plants (living things) and how and as what iron elements are stored in living things FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in explaining the occurrence of zinc transcription

2. Accuracy in conveying the occurrence of iron transport both in microorganisms and in plants

3. Accuracy in explaining the storage of Fe in living things

10
6 Sub-CLO 6:

Able to understand (C2), compose (P4), and discuss (A2) Elemental transport, transfer, and transcription

 

Transport and storage of oxygen

a. Myoglobin and hemoglobin: structure and active site

b. Prosthetic group structure

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturer in group FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in describing the structure of myoglobin and hemoglobin and their active sites

 

2. Accuracy in describing the structure of the prosthetic group

 10
7 Sub-CLO 7:

Able to understand (C2), compose (P4), and discuss (A2) Elemental transport, transfer, and transcription

Transport and storage of oxygen: Mechanism of binding oxygen to metals Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturer in groups FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

Accuracy in explaining the mechanism of binding oxygen to metals in the form of biomolecules (hemoglobin and myoglobin) in the transport and storage of oxygen  5
8 Midterm exam Written exam 90 The truth and completeness of the answer to the question
9 Sub-CLO 8:

Able to understand (C2), compose (P4), and discuss (A2) catalytic processes in biological systems

1. Acid-base catalyst

2. Enzymes related to H2O2 and O2

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problem/task given by the lecturer in groups about reactions catalyzed by acids and bases. What enzymes are associated with hydrogen peroxide and oxygen, and how do these enzymes work? FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in describing reactions in biological systems catalyzed by acids and bases

2. Accuracy in describing enzymes (catalase) associated with H2O2 and O2

3. Accuracy in explaining the performance of the enzyme catalase

 5
10 Sub-CLO 9:

Able to understand (C2), compose (P4), and discuss (A2)  catalytic processes in biological systems

1. Enzyme reactions containing Co (cobalt)

2. Transfer of oxygen atoms by enzymes Molybdenum and tungsten/tungsten

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problem/task given by the lecturer in groups about the catalytic process by enzymes containing Co, Mo, and W and how the reactions occur FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in explaining the reactions of enzymes containing Co

2. Accuracy in explaining how oxygen transfer by Mo and W enzymes

 5
11 Sub-CLO 10:

Able to understand (C2), compose (P4), and discuss (A2) about sensors in biological systems

Iron protein as sensor Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturer in groups FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

Accurately explains iron protein and how it acts as a sensor in biological systems  5
12 Sub-CLO 9:

Able to understand (C2), compose (P4), and discuss (A2) about sensors in biological systems

Proteins containing Cu and Zn as sensors Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturers in groups about proteins containing Cu and Z FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

Accuracy in explaining Cu and Zn proteins as sensors  5
13 Sub-CLO 9:

Able to understand (C2), compose (P4), and discuss (A2) about biomineralization

1. CaCO3

2. Ca5(PO4)X

3.  SiO2

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude problems/tasks given by lecturers in groups regarding biomineralization, how to form . CaCO3, Ca5(PO4)X and SiO2 FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

Accuracy in explaining biomineralization related to its formation 10
14 Sub-CLO 9:

Able to understand (C2), compose (P4), and discuss (A2) about metals that play a role in the medical field

1. Metal toxicity and homeostasis

2. Factors that cause metals to be toxic

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturer in groups FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1.  Accuracy in explaining metal toxicity and homeostasis

2. Accuracy in explaining the factors that cause metals to be toxic

 10
15 Sub-CLO 9:

Able to understand (C2), compose (P4), and discuss (A2) about metals that play a role in the medical field

1. Therapeutic compounds

a. Anti cancer

b. Anti rheumatism

c. Anti-diabetic

 

2. Diagnostic agents

a. Tc imaging agent

b. Gd Imaging Agent

Discovery learning

Cooperative learning

Problem Based Learning

Discuss and conclude the problems/tasks given by the lecturer in groups FF: 1 x (2 x 50”)

ST + SS: 1x(2×60″+2×60″)

1. Accuracy in describing inorganic compounds used as therapeutic and diagnostic agents

2. Accuracy in explaining how the mechanism/performance of inorganic compounds in inhibiting cancer, rheumatism, and diabetes

3. Accuracy in explaining how the mechanism/performance of inorganic compounds in acting as diagnostic agents

 10
16 Final exams Written exam 90 The truth and completeness of the answer to the question
Total Rating 100

Reference:

  1. Bowser, J., 1990, “Inorganic Chemistry”,John Wiley & Sons, New York.
  2. Cotton, F.A & Wilkinson, G., 1987,”Basic Inorganic Chemistry”, John Wiley & Sons, New York.
  3. Manku,G.S., 1980, “Theoritical Principles of Inorganic Chemistry”, Mc. Graw Hill, New York.
  4. Huhey, J.E., 1983, “Inorganic Chemistry Principles of Structure and Reactivity”, 3ed, Harper Inc, New York.
  5. Kaim, Wolfgang and Schwederski, Brigitte, 1994, “Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life”, John Wiley and Sons.
  6. Wilkins,Patricia C. and Wilkins, Ralph G., 1997, “Innorganic Chemistry in Biology”, Oxford University Press. Inc., New York.
  7. Caret, Robert L., Denniston, Katherine J., and Topping, Joseph J., 1993, ” Principles and Aplications of Inorganic, Organic and Biological Chemistry”, Wm. C. Brown Publisher.
  8. Rosette M. Roat-Malone., 2001, “Bioinorganic Chemistry: A Short Course”, John Willey and Sons Inc. Publication

 

Glossary

GLO = Graduate Learning Outcome
CLO = Course Learning Outcomes
FF = Face to Face Learning
ST = Structured tasks
SS = Self Study