SEMESTER LEARNING PLAN
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Course Title: Supramolecular Chemistry (SM)
MK code: AKM21 551
Credit Weight: 2
Group of Courts: Elective
Semester: 5
Prerequisite Course: KRX
Lecturer:
Dr. Parsaoran Siahaan, MS
Graduate Learning Outcomes (GLO)
Attitude  GLO1(S9)  Demonstrate an attitude of being responsible for work in the field of expertise independently 
Knowledge  GLO2(PP1)  Mastering the theoretical concepts of structure, properties, changes, kinetics, and energetics of molecules and chemical systems, identification, separation, characterization, transformation, synthesis of micromolecular chemicals, and their application 
GLO3(PP3)  Mastering the basic principles of software for analysis, synthesis, and molecular modeling in general or more specific chemical fields  
General Skills  GLO4(KU1)  Able to apply logical, critical, systematic, and innovative thinking in the development or implementation of science and technology that pays attention to and uses humanities values by their field of expertise 
GLO5(KU2)  Able to demonstrate independent, quality, and measurable performance  
GLO6(KU5)  Able to make decisions regularly in the context of solving problems in their area of expertise, based on the results of analysis of information and data  
Special skill  GLO7(KK2)  Able to solve science and technology problems in general and straightforward chemical fields such as identification, analysis, isolation, transformation, and synthesis of micromolecules through the application of knowledge of structure, properties, kinetics, and energetics of molecules and chemical systems, with analysis and synthesis methods on specific chemical fields, as well as the application of relevant technologies 
GLO8(KK4)  Able to use software to determine the structure and energy of micromolecules, software to assist analysis and synthesis in general or more specific chemical fields (organic, biochemical, or inorganic), and for data processing (analytical chemistry) 
Course Description
In this course, students learn about the concept of intermolecular interaction theory or noncovalent bonds. This course can use as a basis for understanding surfactants and polymers in drug delivery and liquid crystal phases as drug delivery systems. This course will discuss intermolecular interactions or noncovalent bonds with computational and experimental quantum chemistry methods. This course will cover:
[1] Introduction: understanding and development of supramolecular chemistry.
[2] Electrical properties of a single molecule: charge of the atoms of a molecule, dipole moment, polarizability, relative permittivity, structure, and geometry of the molecule.
[3] Singlemolecule computational methods: calculation of the electrical properties of molecules.
[4] Intermolecular interactions: interaction potential energy, dipoledipole interaction, induced dipoledipole interaction, induced dipole–induced dipole interaction, hydrogen bonding.
[5] Computational method of intermolecular interactions.
[6] Experimental method of supramolecular analysis.
Week  Expected ability (SubCLO)  Study Materials/ Learning Materials  Learning methods  Student Learning Experience  Time (minutes)  Evaluation  
Criteria and Indicators  %  
1  Students can describe (C4analyze), construct (P4), and discuss (A2) single molecules (monomers) and supramolecules and compare (C4analyze) single molecules (monomers) and supramolecules  Introduction: Definition and development of supramolecular chemistry
• Monomers, dimers, supermolecules, and supramolecules. • Noncovalent bonds and molecular associations. • BuildingBlocks. • BottomUp and TopDown Processes 
Discovery learning
Cooperative learning 
Search, collect and organize information to describe supramolecular terms. Discuss and conclude problems/tasks in groups  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accuracy of explaining the meaning of supramolecular  5 
2  Students can describe (C4analyze), construct (P4), and discuss (A2) electrical properties of single molecules and predict (C5evaluate) electrical properties of single molecules  Electrical properties of single molecules
• The charge on the atoms of a molecule. • Electric dipole moment. • Polarisability. • Relative permittivity. • Molecular structure and geometry 
Discovery learning
Cooperative learning 
Discuss and conclude the problems/tasks given by the lecturer in groups  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accurately describes the electrical properties of single molecules  10 
34  Students can describe (C4analyze), construct (P4), and discuss (A2) single molecules and their properties  Singlemolecule computing method
• Ab initio method. • Base set. Calculation of energy and electrical properties of molecules: • Molecular energy • Partial load • Dipole moment • Polarisability • Molecular geometry 
Discovery learning
Cooperative learning Problem Based Learning 
Learn by digging/looking for information (inquiry) and use that information to solve real problems  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accuracy of counting by the singlemolecule computational method.
Accuracy of calculating by computational method given singlemolecule problems 
10 
5  Students can describe (C4analyze), construct (P4), and discuss (A2) Properties of intermolecular interactions and predicting (C5evaluating) properties of intermolecular interactions  Intermolecular Interaction
• Potential energy of interaction. • Dipoledipole interaction: Eg. H_{2}O…H_{2}O. • Dipole interactions – induced dipoles. • Induced dipole interaction – induced dipole: e.g. Cl_{2}…Cl_{2}. • Hydrogen Bonding: e.g., H_{2}O…CH_{3}OH. • Laws of interaction: Mie potential, van der Waals. • Intermolecular interactions of large molecules: e.g., cellulose, chitin, chitosan with vitamin C, water, metalions; zeolite with phenol derivatives. Water and metal ions. • Gibbs free energy, constant of association, constant of inhibition. 
Discovery learning
Cooperative learning Problem Based Learning 
Learn by digging/looking for information (inquiry) and use that information to solve real problems  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accurately describes intermolecular interactions.
Accurately describes intermolecular interactions with given molecular dimer problems. 
10 
67  Students can calculate (C5evaluate) intermolecular interactions and their properties  Computational method of intermolecular interactions
• Ab initio method. • Base set. • Calculation of energy, structure, and geometry of intermolecular interactions, the potential energy of interaction (PESPotential Energy Surface), stability of molecular associations (dimers) 
Discovery learning
Cooperative learning Problem Based Learning 
Learn by digging/looking for information (inquiry) and use that information to solve real problems  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accuracy of calculating by dimer molecule computational method
Accuracy of calculating by the computational method of given dimer molecule problems 
25 
8


Midterm exam  Written exam  90  The truth and completeness of the answer to the question  
910  Students can describe (C4analyze), Properties of intermolecular interactions experimentally by Xray and DSC experiments  Xray and DSC method  Discovery learning
Cooperative learning Problem Based Learning 
Learn by digging/looking for information (inquiry) and use that information to solve real problems  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accuracy of analyzing with Xray and DSC methods.
Accuracy of analyzing the questions with the given Xray and DSC methods 
10 
1112  Students can describe (C4analyze), Properties of intermolecular interactions experimentally by neutron diffraction and IR spectroscopy  Neutron Diffraction and IR Spectroscopy Methods  Discovery learning
Cooperative learning Problem Based Learning 
Learn by digging/looking for information (inquiry) and use that information to solve real problems  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accuracy of analyzing with Neutron Diffraction and IR Spectroscopy methods
Accuracy of analyzing problems with the given method of Neutron Diffraction and IR Spectroscopy 
20 
1315  Students can describe (C4analyze), construct (P4), and discuss (A2)  NMR Spectroscopy Method and Electron Microscopy (AFM – Atomic Force Microscopy)  Discovery learning
Cooperative learning Problem Based Learning 
Learn by digging/looking for information (inquiry) and use that information to solve real problems  FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] 
Accuracy of analyzing with NMR Spectroscopy and Electron Microscopy methods
Accuracy of analyzing the questions with the given NMR Spectroscopy and Electron Microscopy methods 
20 
16  Final exams  Written exam  90  The truth and completeness of the answer to the question 
Reference:
 Lehn, J.M., 1995, “Supramolecular Chemistry: concepts and perspectives“, VCH Verlagsgesellschaft mbH, Weinheim
 Atkins dan de Paula, 2014, Physical Chemistry, 10th ed., W. H. Freeman and Company, New York
 Anslyn, E.V. dan Dougherty, D.A., 2006, “Modern Physical Organic Chemistry”, University Science Books
 Atkins, P. dan De Paula, J., 2006, “Physical Chemistry for the Life Sciences”, Oxford University Press, Oxford
 Van Holde, K.E., Johnson, W.C., dan Shing Ho, P., 2006, Principles of Physical Biochemistry, 2nd ed., Pearson Education, Inc
 Siahaan, P., 2010, “Kimia Supramolekul”, Bahan Ajar, tidak diterbitkan, Jurusan Kimia UNDIP, Semarang
Glossary
GLO = Graduate Learning Outcome
CLO = Course Learning Outcomes
FF = Face to Face Learning
ST = Structured tasks
SS = Self Study