SEMESTER LEARNING PLAN
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Course Title: Supramolecular Chemistry (SM)
MK code: AKM21 551
Credit Weight: 2
Group of Courts: Elective
Semester: 5
Prerequisite Course: KRX
Lecturer:
Dr. Parsaoran Siahaan, MS
Graduate Learning Outcomes (GLO)
| Attitude | GLO1-(S9) | Demonstrate an attitude of being responsible for work in the field of expertise independently |
| Knowledge | GLO2-(PP1) | Mastering the theoretical concepts of structure, properties, changes, kinetics, and energetics of molecules and chemical systems, identification, separation, characterization, transformation, synthesis of micromolecular chemicals, and their application |
| GLO3-(PP3) | Mastering the basic principles of software for analysis, synthesis, and molecular modeling in general or more specific chemical fields | |
| General Skills | GLO4-(KU1) | Able to apply logical, critical, systematic, and innovative thinking in the development or implementation of science and technology that pays attention to and uses humanities values by their field of expertise |
| GLO5-(KU2) | Able to demonstrate independent, quality, and measurable performance | |
| GLO6-(KU5) | Able to make decisions regularly in the context of solving problems in their area of expertise, based on the results of analysis of information and data | |
| Special skill | GLO7-(KK2) | Able to solve science and technology problems in general and straightforward chemical fields such as identification, analysis, isolation, transformation, and synthesis of micro-molecules through the application of knowledge of structure, properties, kinetics, and energetics of molecules and chemical systems, with analysis and synthesis methods on specific chemical fields, as well as the application of relevant technologies |
| GLO8-(KK4) | Able to use software to determine the structure and energy of micromolecules, software to assist analysis and synthesis in general or more specific chemical fields (organic, biochemical, or inorganic), and for data processing (analytical chemistry) |
Course Description
In this course, students learn about the concept of intermolecular interaction theory or non-covalent bonds. This course can use as a basis for understanding surfactants and polymers in drug delivery and liquid crystal phases as drug delivery systems. This course will discuss intermolecular interactions or non-covalent bonds with computational and experimental quantum chemistry methods. This course will cover:
[1] Introduction: understanding and development of supramolecular chemistry.
[2] Electrical properties of a single molecule: charge of the atoms of a molecule, dipole moment, polarizability, relative permittivity, structure, and geometry of the molecule.
[3] Single-molecule computational methods: calculation of the electrical properties of molecules.
[4] Intermolecular interactions: interaction potential energy, dipole-dipole interaction, induced dipole-dipole interaction, induced dipole–induced dipole interaction, hydrogen bonding.
[5] Computational method of intermolecular interactions.
[6] Experimental method of supramolecular analysis.
| Week | Expected ability (Sub-CLO) | Study Materials/ Learning Materials | Learning methods | Student Learning Experience | Time (minutes) | Evaluation | |
| Criteria and Indicators | % | ||||||
| 1 | Students can describe (C4-analyze), construct (P4), and discuss (A2) single molecules (monomers) and supramolecules and compare (C4-analyze) single molecules (monomers) and supramolecules | Introduction: Definition and development of supramolecular chemistry
• Monomers, dimers, supermolecules, and supramolecules. • Non-covalent bonds and molecular associations. • Building-Blocks. • Bottom-Up and Top-Down Processes |
Discovery learning
Cooperative learning |
Search, collect and organize information to describe supramolecular terms. Discuss and conclude problems/tasks in groups | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accuracy of explaining the meaning of supramolecular | 5 |
| 2 | Students can describe (C4-analyze), construct (P4), and discuss (A2) electrical properties of single molecules and predict (C5-evaluate) electrical properties of single molecules | Electrical properties of single molecules
• The charge on the atoms of a molecule. • Electric dipole moment. • Polarisability. • Relative permittivity. • Molecular structure and geometry |
Discovery learning
Cooperative learning |
Discuss and conclude the problems/tasks given by the lecturer in groups | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accurately describes the electrical properties of single molecules | 10 |
| 3-4 | Students can describe (C4-analyze), construct (P4), and discuss (A2) single molecules and their properties | Single-molecule computing method
• Ab initio method. • Base set. Calculation of energy and electrical properties of molecules: • Molecular energy • Partial load • Dipole moment • Polarisability • Molecular geometry |
Discovery learning
Cooperative learning Problem Based Learning |
Learn by digging/looking for information (inquiry) and use that information to solve real problems | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accuracy of counting by the single-molecule computational method.
Accuracy of calculating by computational method given single-molecule problems |
10 |
| 5 | Students can describe (C4-analyze), construct (P4), and discuss (A2) Properties of intermolecular interactions and predicting (C5-evaluating) properties of intermolecular interactions | Intermolecular Interaction
• Potential energy of interaction. • Dipole-dipole interaction: Eg. H2O…H2O. • Dipole interactions – induced dipoles. • Induced dipole interaction – induced dipole: e.g. Cl2…Cl2. • Hydrogen Bonding: e.g., H2O…CH3OH. • Laws of interaction: Mie potential, van der Waals. • Intermolecular interactions of large molecules: e.g., cellulose, chitin, chitosan with vitamin C, water, metalions; zeolite with phenol derivatives. Water and metal ions. • Gibbs free energy, constant of association, constant of inhibition. |
Discovery learning
Cooperative learning Problem Based Learning |
Learn by digging/looking for information (inquiry) and use that information to solve real problems | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accurately describes intermolecular interactions.
Accurately describes intermolecular interactions with given molecular dimer problems. |
10 |
| 6-7 | Students can calculate (C5-evaluate) intermolecular interactions and their properties | Computational method of intermolecular interactions
• Ab initio method. • Base set. • Calculation of energy, structure, and geometry of intermolecular interactions, the potential energy of interaction (PES-Potential Energy Surface), stability of molecular associations (dimers) |
Discovery learning
Cooperative learning Problem Based Learning |
Learn by digging/looking for information (inquiry) and use that information to solve real problems | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accuracy of calculating by dimer molecule computational method
Accuracy of calculating by the computational method of given dimer molecule problems |
25 |
|
8
|
|
Midterm exam | Written exam | 90 | The truth and completeness of the answer to the question | ||
| 9-10 | Students can describe (C4-analyze), Properties of intermolecular interactions experimentally by X-ray and DSC experiments | X-ray and DSC method | Discovery learning
Cooperative learning Problem Based Learning |
Learn by digging/looking for information (inquiry) and use that information to solve real problems | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accuracy of analyzing with X-ray and DSC methods.
Accuracy of analyzing the questions with the given X-ray and DSC methods |
10 |
| 11-12 | Students can describe (C4-analyze), Properties of intermolecular interactions experimentally by neutron diffraction and IR spectroscopy | Neutron Diffraction and IR Spectroscopy Methods | Discovery learning
Cooperative learning Problem Based Learning |
Learn by digging/looking for information (inquiry) and use that information to solve real problems | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accuracy of analyzing with Neutron Diffraction and IR Spectroscopy methods
Accuracy of analyzing problems with the given method of Neutron Diffraction and IR Spectroscopy |
20 |
| 13-15 | Students can describe (C4-analyze), construct (P4), and discuss (A2) | NMR Spectroscopy Method and Electron Microscopy (AFM – Atomic Force Microscopy) | Discovery learning
Cooperative learning Problem Based Learning |
Learn by digging/looking for information (inquiry) and use that information to solve real problems | FF: 1 x (2 x 50”)
ST + SS: 1 x [(2 x 50”) + (2 x 60”)] |
Accuracy of analyzing with NMR Spectroscopy and Electron Microscopy methods
Accuracy of analyzing the questions with the given NMR Spectroscopy and Electron Microscopy methods |
20 |
| 16 | Final exams | Written exam | 90 | The truth and completeness of the answer to the question | |||
Reference:
- Lehn, J.M., 1995, “Supramolecular Chemistry: concepts and perspectives“, VCH Verlagsgesellschaft mbH, Weinheim
- Atkins dan de Paula, 2014, Physical Chemistry, 10th ed., W. H. Freeman and Company, New York
- Anslyn, E.V. dan Dougherty, D.A., 2006, “Modern Physical Organic Chemistry”, University Science Books
- Atkins, P. dan De Paula, J., 2006, “Physical Chemistry for the Life Sciences”, Oxford University Press, Oxford
- Van Holde, K.E., Johnson, W.C., dan Shing Ho, P., 2006, Principles of Physical Biochemistry, 2nd ed., Pearson Education, Inc
- Siahaan, P., 2010, “Kimia Supramolekul”, Bahan Ajar, tidak diterbitkan, Jurusan Kimia UNDIP, Semarang
Glossary
GLO = Graduate Learning Outcome
CLO = Course Learning Outcomes
FF = Face to Face Learning
ST = Structured tasks
SS = Self Study
